Muredach P. Reilly, MBBCH, MSCE, program chair for ATVB/PVD 2015, Kathryn J. Moore, PhD, chair of the council for ATVB, and Michael Conte, MD, chair of the council for PVD, provide their expert perspectives on the science that was presented at the meeting this year in San Francisco with a focus on new approaches for translating science into new patient therapies.