Richard J. Santen, MD, kicked off this important plenary focusing on Menopause on Thursday, March 5, 2015 at the San Diego Convention Center. The Plenary was split into two parts – James Ingle talked about genomics, pharmagenomics, and funcational genomics and its implications for precision medicine. Joann Manson talked about clinical and biomarker data that inform decision making for menopause management.