Zorina Galis, PhD, Chief of the NHLBI Vascular Biology and Hypertension Research Branch, and Muredach Reilly, MBBCH, MSCE, program chair for ATVB/PVD 2015, provide expert perspectives on the science presented at the meeting this year in San Francisco, with an emphasis on a number of opportunities during the meeting for spurring the translation basic ATVB and PVD science into new therapies for patients.